Berberine: Mitochondrial synthesis activator molecule
In this post we are going to talk about what berberine is and how this molecule promotes longevity. Its mechanism of action is genetic: it activates one of the longevity genes, namely AMPK (AMP-activated kinase). Activating this pathway has two effects: it promotes the synthesis of mitochondria and increases sensitivity to insulin in our tissues, two important anti-ageing processes.
What is berberine and what are its benefits?
Berberine is a yellow alkaloid found mainly in Berberis plants, such as Berberis aristata (Indian barberry or tree turmeric).
This molecule acts in our body by directly activating the AMPK pathway. As we have already mentioned, this mechanism has two effects:
1. It increases mitochondrial biogenesis:
Among the many hallmarks of ageing, we find the malfunctioning and decreased biogenesis (synthesis) of mitochondria. These organelles are particularly susceptible to damage over time as they are the main bioenergetic machinery. A decrease in mitochondrial biogenesis results in the accumulation of oxidised forms of lipids, proteins and DNA (known as free radicals).
Effective control of mitochondrial biogenesis and turnover, for example through the use of berberine, is essential for the maintenance of energy production, the prevention of endogenous oxidative stress and the promotion of healthy ageing.
2. It increases our body’s insulin sensitivity:
Insulin is a hormone produced by the pancreas that helps blood glucose enter muscle, fat and liver cells where it is used for energy.
When cells do not respond well to insulin and cannot absorb glucose from the blood easily, we say that the tissues are insulin resistant. It can be caused by being overweight, chronic stress, low physical activity or it can also be due to the effects of aging. If this happens, the glucose level in our blood rises (hyperglycaemia). This situation is very harmful to our bodies as it can damage the blood vessels that carry blood to vital organs, increasing the likelihood of heart disease, stroke, kidney disease, eye problems and neurological problems.
Berberine improves insulin resistance by activating the AMPK pathway, promoting mitochondrial function and stimulating glycolysis (destruction of glucose for energy). This allows normal blood glucose levels to be maintained.
In addition, human studies show that berberine can improve obesity and hyperlipidaemia by reducing triglycerides (TAG) and LDL (bad) cholesterol and increasing HDL (good) cholesterol to support cardiovascular health.
Berberine doses studied range from 1000 to 2000 mg/day.
Did you know…? Berberine is a natural analogue of metformin. Metformin is a drug used to treat type II diabetes and berberine is a molecule that mimics its effects. At no time should berberine replace medication, so if you are undergoing medical treatment, seek advice from your specialist before taking any food supplement. |
Zenement’s Berberine
Each capsule of our Berberine contains 500 mg of berberine sourced from Berberis aristata plant root. In our formula, we combine it with chromium, which contributes to the maintenance of normal blood glucose levels, and piperine to improve absorption of the active ingredients in the capsule.
How to use: 1-2 capsules with a main meals (e.g. breakfast and dinner).
Warnings and Interactions: Berberine should not be taken if you are undergoing treatment with: – Metformin – Immunosuppressants Berberine also has moderate interactions with: – Antitussives such as Dextromethorphan because it slows down the rate at which they are broken down in your body. – Antihypertensive drugs as they may cause your blood pressure to drop excessively. – Anticoagulant or anti-platelet medicines because it may slow down clotting. – Sedative medicines (CNS depressants) as it may cause drowsiness. |
In addition to this post, we recommend you read our 9 tips to delay ageing and live longer and better. You may also be interested in our article on Resveratrol and Quercetin, anti-ageing food supplements.
Related products
-
Zinc, 25mg (Bisglycinate)
Price: €13.61💥 BENEFITS OF ZINC: Zinc is an essential mineral involved in many enzymatic... -
Vitamin C, 1000mg per tablet
Price: €16.34🍊 BENEFITS OF VITAMIN C: Vitamin C, or ascorbic acid, is an antioxidant,... -
Reduced Liposomal L-Glutathione + Vitamin C
Price: €23.61⭐ LIPOSOMAL FORMULA WITH MAXIMUM BIOAVAILABILITY: Our liposomal formula is up... -
Biotin, 10000mcg per tablet with Selenium and Zinc
Price: €15.43💆🏽♀️ BIOTIN 10000MCG PER TABLET WITH SELENIUM AND ZINC: contributes to the... -
Marine Collagen Complex, with Hyaluronic Acid, CoQ10, Vitamins C & E, & Zinc
Price: €18.61🌊 MARINE COLLAGEN COMPLEX: Peptides to help you regenerate the body's... -
Natural Vitamin E - 400 IU, (D-Alpha-Tocopherol)
Price: €18.15🪴 NATURAL VITAMIN E (D-alpha-tocopherol): More effective than synthetic... -
Natural Vitamin E Complex, Tocopherols & Tocotrienols
Price: €22.70🪴 FULL SPECTRUM: With the 8 forms of vitamin E, 4 forms of Tocopherols... -
Moringa, 600mg per capsule
Price: €17.25💥 ENERGIZING SUPERFOOD: Moringa Oleifera is considered a superfood thanks to... -
CoQ10, 200mg per softgel
Price: €23.15💥 ABSORPTION AND BIOAVAILABILITY ARE KEY: Most CoQ10's use the dry (powder)... -
Turmeric Curcumin, with Black Peper
Price: €16.34💥 POWERFUL ANTIOXIDANT: Powerful plant antioxidant that prevents inflammation... -
Solar Care, with Polypodium leucotomos, Green Tea, Carotenoids, Selenium and Vitamins A, C, D & E
Price: €15.43☀️ SOLAR CARE: With Polypodium leucotomos, Green Tea, Carotenoids, Selenium... -
Berberine, from Berberis Aristata Root Extract
Price: €19.06🏔️ THE BEST BERBERIS ARISTATA ROOT EXTRACT: Our extract derives from the... -
Spermidine 2mg per capsule
Price: €22.70⏳ CELL RENEWAL ELIXIR: Spermidine is a substance naturally present in our... -
Trans-Resveratrol 500mg per capsule
Price: €28.15REVOLUTIONARY TRANS-RESVERATROL FORMULA, NOW WITH NAD+: Enhance your... -
Antiox Cell Regenerator
Price: €15.43⏳ OPTIMAL RESULTS with the optimal combination of Antioxidant properties of... -
Astaxanthin, 5mg per softgel with Omega 3
Price: €18.15💥 POTENT ANTIOXIDANT: To give you an idea of the antioxidant power of... -
Quercetin, with Bromelain
Price: €26.34⭐ THE MOST COMPLETE FORMULA WITH MAXIMUM ABSORPTION: Our formula combines... -
Liposomal Vitamin C 1000mg
Price: €21.79⚡ MAXIMUM ABSORPTION LIPOSOMAL FORMULA: Unlike other products, our Liposomal... -
L-Taurine 500mg per capsule
Price: €14.52🏋🏽♂️ INCREDIBLE BENEFITS OF OUR AMINO ACID NUTRITIONAL SUPPLEMENT: L Taurine... -
NAC N-Acetyl-Cysteine, 600mg
Price: €18.15⭐ PREMIUM AMINO ACID: N-Acetyl-Cysteine (NAC) is a stable form of the amino... -
Organic Cordyceps Sinensis Extract 40% Polysaccharides
Price: €22.70🪴 ORGANIC CORDYCEPS, WITH 40% POLYSACCHARIDES: Adaptogenic mushrooms such as... -
OPC 530mg per capsule
Price: €21.79EXCEPTIONAL CONCENTRATION: Discover our Grape Seed Extract with an incredible... -
Vitamin C Gummies with Zinc
Price: €12.70HIGH DOSE, BETTER TOLERANCE: Unlike other products, our delicious orange...
Related posts
-
How to prevent hair loss?
23/11/2022In our daily lives we are exposed to different factors that can cause our hair to fall out to a greater or lesser...Read more
-
We give you the keys to prevent cardiovascular diseases!
Posted in: Cardiovascular Health25/11/2021"Cardiovascular disease" is a broad term that is linked to heart and blood vessel disorders. Such ailments are often...Read more
-
New European regulation on monacolins for red yeast rice food supplements
Posted in: Cardiovascular Health04/05/2022As of May, red yeast rice yeast food supplements must contain less than 3 mg of Monacolin K per daily dose to comply...Read more
-
How to take care of your skin during the summer?
Posted in: Antiageing & Beauty27/06/2022Taking care of your skin all year round keeps it healthy, elastic and helps to delay the appearance of wrinkles. But...Read more
-
How does Omega-3 improve our health?
Posted in: Cardiovascular Health31/08/2022Omega-3 is an essential fatty acid that we need to include in our diet on a regular basis, since mammals cannot...Read more